Job Description

Requisition Number 07105
Department Name: Integrative Structural and Computational Biology
Position Type: Full Time
Position Title Postdoctoral Associate- Roy Lab
Position Summary:

This appointment is to work within the laboratory of Dr. Raktim Roy and will focus on the structure determination as well as the functional characterization of Non-Ribosomal Peptide Synthetase systems. The Roy Lab is a new lab at Scripps Research located in Jupiter, Florida. The principle focus will include an understanding the mechanism of NRPS dependent synthesis of peptide products. The candidate is expected to contribute to all aspects of the project including cloning, expression and purification of target proteins, as well as all operations of the X-ray crystallography (crystallization, data collection, data processing and structure determination). The candidate will also be involved in functional studies involving, molecular biology, mutagenesis and biochemistry. Successful candidates will work in a cutting-edge research environment that explores the new field of the NRPS biology.

Position Description

Postdoctoral Associates are appointed positions for the purpose of developing scholarly competence and working under the supervision of a TSRI Faculty member. Post-Doctoral associates will join an exciting research environment in new state-of-the-art facilities of the Scripps-Florida campus of The Scripps Research Institute (TSRI), which is renowned in the Structural Biology field. The position provides an outstanding training program in protein biochemistry and structure, and also in molecular and cellular biology, in a highly dynamic environment of a young lab. Successful candidates will work in a cutting-edge research environment that tackles this important new arena in structural and cell biology. These appointments are normally not renewed beyond a total of 5 years. Postdoctoral Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Postdoctoral Associates do not have consulting privileges.

Location: Florida
Additional Information:

Scripps-Florida provides an incredibly rich scientific environment. Notably, TSRI faculty include an outstanding cadre of senior colleagues, including two Nobel Laureates and twenty Members of The National Academy of Sciences, including several in crystallography and biophysics. In 2008, Scripps-Florida moved into three new, state-of-the-art research buildings and will expand to eventually house 80 faculty-level investigators.

Scripps-Florida has a large cast of outstanding Cores that facilitate basic research and drug development. The unique infrastructure at Scripps-Florida includes the application of unique chemical, genomic, proteomic, informatics, and high-throughput screening and engineering tools for the discovery of novel biomolecules.

Scripps-Florida is a member of the South East Regional Collaborative Access Team (SER-CAT) that constructed two beam lines at the Advanced Photon Source (APS) at Argonne National Laboratory. The insertion device and bending magnet beam lines are available for all the synchrotron-related data collection needs for the post-doctoral fellows.

Scripps-Florida provides a HighFlux X-ray diffraction system, specifically a Rigaku MicroMax-007 HF, a second-generation true microfocus rotating anode generator. Scripps-Florida also provides an Osmic VariMax optics system and the Proteros Free Mounting System to control the humidity and to optimize diffraction characteristics, including resolution, mosaicity, and anisotropy, as well as reduced X-ray background. Finally, the X-ray laboratory houses the mar345 Image Plate detector.

Palm Beach County is one of the most sought-after communities in the country and offers residents an incomparable lifestyle in a family-friendly community with public playgrounds and parks and access to world-class shopping and unmatched outdoor recreation. The Atlantic Ocean with its 45 miles of spectacular beaches and signature Coconut Palms provides an exclusive getaway in a warm, sunny climate throughout most of the year. There are a number of exquisite art galleries as well as arts and crafts festivals. This golfer’s paradise is also home of the Professional Golfers Association of America (PGA).

Physical Requirements:

This position works in a laboratory or vivarium environment. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process.

Basic Qualifications:

Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.

Please send CV, brief summary of research experience and interests, and names, addresses, e-mail, and telephone numbers of 3 references to:

Dr. R. Roy (raktimroy@scripps.edu)
NRPS Laboratory
Department of Integrative Structural and Computational Biology
The Scripps Research Institute
Jupiter, FL 33458

Preferred Qualifications:

Applicants with a recently awarded Ph.D. degree in Biochemistry/ Structural Biology and experience in protein crystallography is preferred.

Compensation:
Job Closing Date:
Open Until Filled Yes
Job Posting Category Postdoctoral
EEO Statement

The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.

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