Job Description

Requisition Number 06140
Department Name: Immunology and Microbiology - CA
Position Type: Full Time
Position Title Postdoctoral Associate
Position Summary:

An NIH funded Postdoctoral Associate position is available immediately in the Zwick lab as part of an interdisciplinary research project in HIV vaccine design.

The successful candidate will (1) create and improve on novel immunogens based on the membrane embedded form of the envelope glycoprotein of HIV-1 arrayed multivalently on VLPs and liposomes; (2) sort/screen for B cells that produce broadly neutralizing antibodies (bnAbs) in vaccinated animals and HIV-positive humans, particularly those against gp41 epitopes associated with protection; (3) study B cell specificities to inform the re-design of immunogens and improve bnAb responses in animal models.

The candidate will be encouraged to learn and then apply cutting-edge technologies to address critical problems facing next-generation vaccine design. There will be opportunities to interact with clinical researchers, experts in B cell repertoire analysis, and structural biologists, the latter to determine X-ray and cryo-EM structures of antibodies in complex with HIV envelope. Additional training opportunities exist at Scripps in science writing and career development.

Responsibilities:
-Single B cell analysis of HIV bnAb responses in humans and animals
-Antibody cloning and analysis by various immunoassays
-Work with an inter-disciplinary team on NGS of B cell lineages, structures of antibodies in complex with HIV Env, and contribute to the design of Env vaccines with improved capacity to drive bnAb responses
-Contribute to manuscript and grant writing

Position Description

A postdoctoral position is available for a talented scientist interested in HIV-1 vaccine design. The successful candidate will be engaged in research to develop novel immunogens based on the membrane envelope glycoprotein of HIV; single B cell sorting of broadly neutralizing antibody (bnAb) in vaccinated animals as well as in HIV-1 positive donors; elucidating mechanisms of neutralizing antibodies.

Location: California
Additional Information:

* Candidate must be self-motivated, work well both independently and as part of a team, and practice critical thinking skills.
* Interested applicants should email Dr. Michael Zwick, zwick@scripps.edu. Please include a brief description of your interest in the position and career goals, CV, and the names of three academic references.

Physical Requirements:

This position works in a laboratory or vivarium environment. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process.

Basic Qualifications:

Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.

Preferred Qualifications:

The preferred candidate will have recently obtained a PhD with training in immunology, molecular biology, microbiology or related discipline. Experience or background in vaccine research, flow cytometry, protein engineering, or bioinformatics will be useful for this position.

Compensation:
Job Closing Date:
Open Until Filled Yes
Job Posting Category Postdoctoral
EEO Statement

The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.

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