The Briney lab combines cutting-edge sequencing technology and computational immunogenetics approaches to investigate protective immune responses to viral infection. We have active research projects in several areas, including HIV, Lassa and Ebola.
We are looking for a postdoc to lead a new systems immunological project focused on Lassa and Ebola. The goals of this project are identifying functional and genetic features in the adaptive immune response that are associated with desirable clinical outcomes. This position is part of a larger initiative with the recently established Center for Viral Systems Biology (https://cvisb.org).
Primary tasks will include: * Create and improve techniques for large-scale, cost efficient sequencing of adaptive immune receptor repertoire (TCR and BCR). * Oversee and directly participate in the isolation and characterization of neutralizing monoclonal antibodies from survivors of Lassa and Ebola infection. * Work closely with computational biologists to develop novel computational tools for evaluation of antibody repertoire development, maturation and function. Interested candidates should submit their CV and cover letter to email@example.com. Please have at least three referees email their references directly to firstname.lastname@example.org.
This position works in a laboratory or vivarium environment. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process.
Requirements include: * Ph.D. in immunology, genetics, molecular biology, or similar is required. A pending doctoral degree may be considered with approval of the Principal Investigator. * Independent, highly motivated and passionate about harnessing emerging technology to answer fundamental questions about viral immunology. * Familiarity with common molecular biology techniques (cloning, protein production and purification, assessment of antibody binding/neutralization) is highly desirable. * Experience performing next-generation sequencing is highly desirable, especially experience with the 10X Genomics Chromium platform or other microfluidics-based single cell analysis platforms. * Experience handing and manipulating large sequence datasets is highly desirable. * Programming skills in a scripting language (our lab primarily uses Python) are not required but would be a major plus. Although programming proficiency is not required, the ability to assist in the development of novel computational tools by providing immunological guidance and support to computationally-focused lab members is critical. * Strong interpersonal skills and the ability to work with and mentor junior scientists and students.
Job Closing Date:
Open Until Filled
Job Posting Category
The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
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