Calibr, a division of Scripps Research is a not-for profit research institute located in La Jolla, California. Calibr is focused on innovative early stage translational research in the areas of regenerative medicine, cancer biology, cardiovascular and metabolic disease, immunology and infectious disease. Position Overview: The California Institute for Biomedical Research (Calibr) is seeking talented Medicinal and Synthetic Postdoctoral Fellow candidates to join a dynamic, interdisciplinary team of scientists focused on early stage translational research. Postdoctoral researchers in the medicinal chemistry group will work as part of a team of scientists to synthesize and characterize small molecules that represent new therapeutic approaches to unmet medical needs. The researcher will be synthesizing and designing analogs designed to optimize the potency, pharmacokinetics, safety and in vivo efficacy of potential drug candidates. Work will be published in high-impact, peer-reviewed journals. Essential Duties and Responsibilities: * Conduct structure-activity relationship (SAR) study to perform the optimization * Design the analogs of the lead compounds based on the computer-aided molecular modeling, literature research and medicinal chemistry principles * Synthesis and analysis the target molecules using varieties of techniques such as organic synthesis, column chromatography, HPLC analysis, nuclear magnetic resonance (NMR), MS/IR/UV spectroscopy, etc. * Generate candidates with drug-like properties for progression to clinical studies
San Diego, California
This position works in a laboratory or vivarium environment. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process.
Ph.D. in chemistry * Strong skills and a proven track record in synthetic organic chemistry, compound purification, and structural characterization
Job Closing Date:
Open Until Filled
Job Posting Category
The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.
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