Job Description

Requisition Number 07046
Department Name: Immunology and Microbiology - CA
Position Type: Full Time
Position Title Postdoctoral Associate
Position Summary:

The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the associated coronavirus disease 2019 (COVID-19) has precipitated a global pandemic heavily challenging our social behavior, economy, and healthcare infrastructure. Prediction models project U.S. COVID-19 deaths exceeding 130,000 in Summer 2020. Worldwide, recovery from this active, devastating outbreak cannot begin until safe and effective medicines for treatment and prevention are available. Currently, there are no approved drugs, immune therapeutics, or vaccines against SARS-CoV-2.

A postdoctoral position is immediately available to test the efficacy and safety of a new vaccine candidate developed in our lab. This vaccine consists in the transduction of human ACE2 (hACE2) entry receptor transgenic mice with a Sindbis vector encoding selected SARS-CoV-2 proteins. Immune response and viral protection against SARS-CoV-2 challenge will be analyzed. Presence of the virus in multiple organs (i.e., lungs) will be analyzed by immunostaining of organ sections and by viral infectivity using plaque assays and qPCR. Neutralization of the mounted response (i.e., antibodies) will be analyzed ex vivo using various cell culture systems developed in our lab. Moreover, new drug candidates available in our lab will be tested for safety and efficacy for the treatment of SARS-CoV-2 infection both in vitro and infected hACE2 transgenic mice.

Position Description
Location: San Diego, California
Additional Information:
Physical Requirements:

This position works in a laboratory and vivarium environment (Biosafety level 2 and 3). Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process.

Basic Qualifications:

Must possess a Ph.D. A pending doctoral degree may also be considered with approval of the Principal Investigator. Please send a curriculum vitae (CV) to Dr. Philippe Gallay at gallay@scripps.edu. Lab website: http://www.scripps.edu/gallay

Preferred Qualifications:

Background in virology and/or mouse work expertise

Compensation: Salary is commensurate with experience.
Job Closing Date:
Open Until Filled Yes
Job Posting Category Postdoctoral
EEO Statement

The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.

Application Instructions

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