Job Description

Requisition Number 06042
Department Name: Molecular Medicine - CA
Position Type: Full Time
Position Title Postdoctoral Associate
Position Summary:

We are seeking a highly talented and motivated individual with a strong background in synthetic organic chemistry to join our medicinal chemistry program as a postdoctoral associate in the department of Molecular Medicine at The Scripps Research Institute. We are seeking to develop and optimize S1PR3-selective ligands with improved potency, selectivity and pharmacokinetic properties. Current S1P receptor ligands will be optimized for potency and functional selectivity for S1PR3 versus other S1P receptor family members; S1P1, S1P2, S1P4 and S1P5. Physicochemical properties of S1PR3 selective compounds including microsome stability, solubility, total polar surface area and pharmacokinetics properties will be optimized for in vivo use.

Location: California
Additional Information:

We are seeking a highly talented and motivated individual with a strong background in synthetic organic chemistry to join our medicinal chemistry program as a postdoctoral associate in the Department of Molecular Medicine at The Scripps Research Institute. We are seeking to develop and optimize S1PR3-selective ligands with improved potency, selectivity, and pharmacokinetic properties. Current S1P receptor ligands will be optimized for potency and functional selectivity for S1PR3 versus other S1P receptor family members; S1P1, S1P2, S1P4, and S1P5. Physicochemical properties of S1PR3 selective compounds including microsome stability, solubility, total polar surface area and pharmacokinetics properties will be optimized for in vivo use.

The selected candidate will participate in the molecular design, synthesis, analysis of SAR and DMPK data. Specifically, the primary responsibility of the candidate will be in the lab designing and synthesizing novel chemical compounds to optimize potency, selectivity, pharmacokinetics and in vivo efficacy. As a member of a dynamic, multi-disciplinary team, the selected candidate will collaborate closely with a broad group of scientists within The Scripps Research Institute and contract research organizations (CROs).

Physical Requirements:

This position works in a laboratory or vivarium environment. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process.

Basic Qualifications:

Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.

Applicants must have PhD in synthetic organic chemistry and be a first author on at least 2-3 publications. This position requires extensive experience in designing synthetic routes for new classes of compounds, solving challenging synthetic problems. Applicants need an expertise in using HPLC, NMR and MS for organic chemistry applications.

Preferred Qualifications:
Compensation:
Job Closing Date:
Open Until Filled Yes
Job Posting Category Postdoctoral
EEO Statement

The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.

Application Instructions

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