Job Description

Requisition Number 06443
Department Name: Calibr
Position Type: Full Time
Position Title Research Associate/ Research Scientist, Protein Science
Position Summary:

Job ID: N175- Research Associate/Research Scientist
Calibr, a division of Scripps Research is a not-for profit research institute located in La Jolla, California. Calibr is focused on innovative early stage translational research in the areas of regenerative medicine, cancer biology, cardiovascular and metabolic disease, immunology and infectious disease.

Position Overview:
Calibr at Scripps Research is seeking talented candidates in Molecular Biology and Protein Engineering. The position functions as part of a small team of interdisciplinary scientists to develop novel protein therapeutics both in the cellular immunotherapy/immuno-oncology and antibody fields. The successful candidate will play an integral role generating therapeutic candidates for our switch-based CAR-T platform and bispecific antibody program and demonstrate a good understanding of technologies required for developing proprietary biotherapeutics.

Calibr’s exciting and dynamic research environment offers a unique perspective on bench to bedside translational research. Calibr’s open lab space design and collaborative research environment encourages the seamless flow of ideas within and between research groups. Further, the association with Scripps Research links world-class basic research innovation with patient-centric research initiatives, to elevate the scientific discourse and accelerate the discovery and development of new medicines. This opportunity is ideal for individuals with a passion for science and a strong drive to make an impact.

Essential Duties and Responsibilities:
* Hands on, wet lab experiments are core to the scope of work including, but not limited to molecular cloning, protein expression and purification, and biophysical characterization of therapeutic candidates.
* Molecular biology activities include DNA isolation and purification, construct design, and assembly-based cloning.
* Expression of recombinant proteins in mammalian and bacterial systems.
* Column-based protein purification by gravity and automated chromatography methods.
* Characterization of proteins by SDS-PAGE, LC/MS, HPLC-based chromatography, and ELISA.
* Prepare scientific and technical documents including detailed data reports, protocols and SOPs, CMC documentation and regulatory filings.

"The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status."

Location: California
Additional Information:
Physical Requirements:

This position works in a laboratory or vivarium environment. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process.

Basic Qualifications:

Qualifications and Experience:
* Candidates for the position must possess a BS, MS, or PhD with 3-5 years of experience in protein science, molecular biology, or related field - experience with antibody engineering is preferred.
* Proficiency in DNA/RNA isolation and purification, classical and assembly-based cloning methods, site-directed mutagenesis, and PCR is required. Experience in qPCR, cDNA library construction, genome engineering, and phenotypic directed antibody selection is a plus.
* Experience with mammalian cell expression in HEK and/or CHO cells is required. Experience with hybridoma cell lines is a plus.
* Proficiency with column-based chromatography, AKTA instrumentation, and UNICORN software is essential.
* Experience with protein analytics, including SDS-PAGE, ELISA, HPLC chromatography, and protein mass spectrometry is highly preferred. Experience with capillary electrophoresis (CE), surface plasmon resonance (SPR), biolayer interferometry (BLI), and/or dynamic light scattering (DLS) is a plus.
* Working knowledge of Microsoft Office applications and instrument specific software.
* Must possess a strong work ethic, attention to detail, and excellent problem-solving skills.
* The candidate must have excellent oral and written communication skills in English.

Preferred Qualifications:
Compensation:
Job Closing Date:
Open Until Filled Yes
Job Posting Category Scientific & Technical
EEO Statement

The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.

Application Instructions

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