Job Description

Requisition Number 06026
Department Name: Calibr
Position Type: Full Time
Position Title Research Scientist CAR-T Cell Therapy (Calibr)
Position Summary:

Job ID: N162
This position is with the California Institute for Biomedical Research (Calibr).
To learn more about this opportunity and/or to apply for consideration, please go to https://www.scripps.edu/science-and-medicine/calibr/careers/


The California Institute for Biomedical Research (Calibr) is a not-for profit research institute located in La Jolla, California. Calibr is focused on innovative early stage translational research in the areas of regenerative medicine, cancer biology, cardiovascular and metabolic disease, immunology and infectious disease.

The California Institute for Biomedical Research (Calibr), a close affiliate of Scripps Research, is seeking talented Research Scientist candidates in the area of Cell Therapy, to join our team.

This position will work within of a small team of interdisciplinary scientists to translate novel cellular therapies for the treatment of cancer into human clinical trials. Specifically, this position work alongside other research scientists in the development of Calibr’s novel universal, switchable CAR-T cell platform. The Research Assistants or Research Associate will play an integral role in Calibr’s target discovery program which will focus on the translation of novel CAR-T strategies to solid tumors.

Calibr’s exciting and dynamic research environment offers a unique perspective on bench to bedside translational research. Calibr’s open lab space design and collaborative research environment encourages the seamless flow of ideas within and between research groups. Further, the association with The Scripps Research Institute links world-class basic research innovation with patient-centric research initiatives, to elevate the scientific discourse and accelerate the discovery and development of new medicines. This opportunity is ideal for scientists with a passion for science and a strong drive to make an impact.

Essential Duties and Responsibilities:

  • Cell biology including working with primary human immune cells and culturing multiple cell lines including, but not limited to, common tumor cell lines used in immuno-oncology research.
  • Design and execution of project plans involving immune cell profiling, cell processing from xenograft models, cytotoxicity, proliferation, activation, cell viability, and survival assays with a strong focus on flow cytometry.
  • Generation of reagents for projects including preparation of lentivirus for transduction of both established cell lines and primary immune cells.
  • Molecular biology experiments including DNA and protein preparation from cells, immunoprecipitation, Western blots, etc will be within the scope of work.
  • Preparation of reports and presentation of results at regular team meetings.
Location: California
Additional Information:

This position is with the California Institute for Biomedical Research (Calibr).
To learn more about this opportunity and/or to apply for consideration, please go to https://www.scripps.edu/science-and-medicine/calibr/careers/

Physical Requirements:

Physical Demands and Work Environment
The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the functions.

Details of established essential functions for this position will be addressed/discussed during the interview process

Basic Qualifications:
  • A strong background in cell culture is essential.
  • Hands on experience in cellular immunotherapies and gene editing is strongly preferred.
  • Experience with multi-color flow cytometry and flow data analysis is required.
  • Experience and knowledge of the immune system is a required. Experience in T cell biology, tumor immunology, as well as other immune components is preferred.
  • Hands-on experience with in vitro assays commonly used in immuno-oncology, and experience preparing reagents for in vivo assays.
  • Experience with cell transfection and viral vector-based transduction systems is preferred.
  • Experience with molecular biology techniques is preferred.
  • Experience using Prism, FlowJo, and Office software is important.
  • In vivo experience preferred but not required.
    Qualifications:
  • BS, BA, MA, MS, or PhD in immunology (preferred), biology, chemical biology, biochemistry or related area with 3-8 years’ experience in industry. Prior postdoc experience is not required.
  • Highly motivated, creative, and devoted to project goals.
  • Impeccable attention to detail, and excellent ability to perform hands on experiments, research, design, and organize project designs and maintain detailed documentation.
  • Able to collaborate proficiently and communicate effectively with colleagues and management teams.
  • Able to contribute in a meaningful way to scientific discourse.
Preferred Qualifications:
Compensation: Commensurate with experience
Job Closing Date:
Open Until Filled Yes
Job Posting Category Scientific & Technical
EEO Statement

The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.

Application Instructions

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