Job Description

Requisition Number 07115
Department Name: Biology - Hampton
Position Type: Full Time
Position Title Research Scientist
Position Summary:

Calibr is a translational research institute located in La Jolla, California, now a part of Scripps Research. Calibr was founded on the principle that the creation of new medicines can be accelerated by pairing world-class biomedical research with state-of-the-art drug discovery and development capabilities. Leveraging the unique scientific framework of Scripps Research, Calibr is shaping a new paradigm for advancing nonprofit biomedical research to impact patients while re-investing in further innovative research.

We are seeking a talented Research Scientist to join our Protein Engineering group. The candidate will be responsible for molecular biology activities and protein production to support existing biotherapeutic programs and develop new ideas at the forefront of immunotherapy. This includes programs in cellular immunotherapy, the development of novel immuno-oncology targets, and the use of protein engineering technologies to develop new therapeutics.

Essential Duties and Responsibilities:
* Responsibilities are focused on, but not limited to molecular cloning, protein expression and purification, and biophysical characterization of therapeutic candidates.
* Molecular biology activities include DNA isolation and purification, construct design, and assembly-based cloning.
* Expression of recombinant proteins in mammalian and bacterial platforms.
* Column-based protein purification by gravity and instrument-based chromatography methods.
* Characterization of proteins by existing methodologies and development of new biophysical assays.
* Prepare scientific and technical documents including detailed data reports, protocols and SOPs, CMC documentation and regulatory filings.

Position Description
Location: San Diego, California
Additional Information:
Physical Requirements:

Details of established essential functions for this position will be addressed/discussed during the interview process.

Basic Qualifications:

Requires a Bachelor’s degree in a relevant scientific discipline or an equivalent combination of education, training and/or experience from which comparable knowledge, skill and abilities have been attained. Requires a minimum of 10 years experience. Candidates possessing a Master’s degree, a minimum of 7+ years experience required.  

  • Candidates must possess a BS with 10 years, MS with 7+ years or PhD with 1-3 years of experience in protein science, molecular biology, or other relevant field.
  • Proficiency in DNA/RNA isolation and purification, classical and assembly-based cloning methods, site-directed mutagenesis, and PCR is required.
  • Experience in qPCR, library construction, NGS platforms, and phenotypic directed antibody selection is a plus.
  • Experience with mammalian cell expression in HEK and/or CHO cells is required. Experience with hybridoma cell lines is a plus.
  • Proficiency with column-based chromatography, AKTA instrumentation, and UNICORN software is essential.
    Experience with capillary electrophoresis (CE), surface plasmon resonance (SPR), biolayer interferometry (BLI), and/or dynamic light scattering (DLS) is a plus.
  • Previous project leadership and/or supervision of junior scientific staff members is a plus.
  • Must possess a strong work ethic, attention to detail, and excellent problem-solving skills.
  • Must have excellent oral and written communication skills in English.
Preferred Qualifications:
  • Experience with antibody engineering is preferred.
  • Experience with protein analytics, including SDS-PAGE, ELISA, HPLC chromatography, and protein mass spectrometry (LC/MS) is highly preferred.
Compensation: DOE
Job Closing Date:
Open Until Filled Yes
Job Posting Category Scientific & Technical
EEO Statement

The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.

Application Instructions

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