Job Description

Requisition Number 05497
Department Name: Chemistry - FL
Position Type: Full Time
Position Title Staff Scientist
Position Summary:

The Scripps Research Institute (TSRI) is currently seeking a Staff Scientist in the area of rational design of small molecules targeting RNA. The selected candidate will work in the laboratory of Dr. Matthew Disney, in the Chemistry Department for its Florida facility.

The selected candidate will conduct research using a combination of approaches to rationally design small molecules targeting RNA (J. Am. Chem. Soc. 2012, 134(10): 4731-4742; ACS Chem. Biol. 2012, in press; and, ACS Chem. Biol. 2012, 7(3): 496-505). Several compounds have been successfully developed to target repeating RNA transcripts that cause diseases such as Myotonic Dystrophy, Huntington’s Disease, et cetera. We are seeking qualified individuals to contribute to future developments in this area including: (i) using a library-versus-library screen to identify and annotate RNA-ligand interactions (described in J. Am. Chem. Soc. 2011, 133(26): 10111-10118 and Angew. Chem. Int. Ed. Engl. 2010, 49(22): 3816-3818); (ii) using computationally approaches (RNA structure modeling) to identify new RNA targets for small molecules from human genomic sequence; and (iii) further develop lead bioactive compounds in a variety of cellular and animal model systems.

Our laboratory is located at The Scripps Research Institute in Jupiter, Florida. Students interested in careers in academia or in industry are well suited for these positions. Scripps Florida houses high throughput screening, DMPK, and other facilities that uniquely position us for translational research.

Location: Florida
Additional Information:
Physical Requirements:

This position works in a laboratory or vivarium environment. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process.

Basic Qualifications:

Ph.D. in an appropriate scientific discipline required. A minimum of 2 years postdoctoral experience.

Prefer applicants with more experience.

Qualified candidates should have a PhD in a related scientific discipline and an established background in Bioorganic Chemistry, Chemical Biology, Cellular and Molecular Biology or Medicinally Related field. Previous experience in RNA folding, RNA biochemistry/biophysics, or nucleic acids biochemistry/biophysics is highly desirable.

Appointments as a Staff Scientist can be made by any member of the TSRI Faculty upon approval of the Departmental Chair. Staff Scientists must be at least .5 FTE.
Administrative Guideline Policy 3.1K

Preferred Qualifications:

Florida & Palm Beach County residents are preferred.

Compensation: Commensurate with experience
Job Closing Date:
Open Until Filled Yes
EEO Statement

The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.

Application Instructions

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